Best Dog Heartworm Treatment (Jan 2023 Update)

When you shop through links on our site, we may earn an affiliate commission. This educational content is not intended to be a substitute for professional advice.

Are you looking for the Best Dog Heartworm Treatment? If so, you’ve come to the right place.

Choosing the Best Dog Heartworm Treatment can be difficult as there are so many considerations, such as Bayer, Durvet, Elanco, Merial, Sentinel, SENTRY, VetOne, Virbac, Zoetis. We have done a lot of research to find the top 20 Best Dog Heartworm Treatment available.

The average cost is $43.74. Sold comparable range in price from a low of $5.99 to a high of $125.99.

Based on the research we did, we think Tri-Heart Plus Chewable Tablets for Dogs, 51-100 lbs is the best overall. Read on for the rest of the great options and our buying guide, where you can find all the information you need to know before making an informed purchase.

20 Best Dog Heartworm Treatment (20 Sellers)

1. Tri-Heart Plus Chewable Tablets For Dogs, 51-100 Lbs

Product Details:

Specifications:

Reviews:

2. Interceptor Plus Chewable For Dogs, Yellow 25.1-50 Lbs 6 Doses

Product Details:

Specifications:

Reviews:

3. Trifexis Heartworm And Flea Prevention Chewable Tablets For Dogs (Spinosad + Milbemycin Oxime) By Elanco Animal Health Orange 6 Ct (10-20 Lbs) Orange

Product Details:

Specifications:

Reviews:

4. Heartgard Plus Chewables Up To 25lb 12 Month

Product Details:

Specifications:

Reviews:

5. Trifexis Chewable Tablets For Dogs, Blue – 6 Count

Product Details:

Specifications:

Active Ingredient Trifexis Pink

Reviews:

6. Heartgard Plus For Dogs

Product Details:

Specifications:

Weight and Color 1-25 lbs Blue

Reviews:

7. Trifexis For Dogs – 6 Pack Size: 20.1-40 Lbs

Product Details:

Reviews:

8. Sentinel Flavored 2-10 Lbs 6 Doses Flavor Tabs For Dogs

Product Details:

Specifications:

Reviews:

9. Tri-Heart Plus Chewable Tablets For Dogs, 1-25 Lbs

Product Details:

Reviews:

10. Heartgard Plus For Dogs – 51-100 Lbs (12 Chews)

Product Details:

Specifications:

Reviews:

11. Sentinel Spectrum Chewables For Dogs 25.1 To 50 Lbs, 6 Month Supply

Product Details:

Specifications:

Reviews:

Easy to open single serving pack for each month. My dog loves the taste and thinks it's a treat. No complaints!BumbleBee_Frenchie
Vet recommended! Will always use this for my dog. Reliable productGmari

12. Interceptor Green, Dogs 11-25lbs / Cats 1.5-6lbs. 12 Month Supply

Product Details:

Reviews:

13. Tri-Heart Plus Chewable Tablets For Dogs, 26-50 Lbs

Product Details:

Reviews:

14. Intervet Safe-Guard Canine Dewormer – 3 Pack, 4 G Packets

Product Details:

Specifications:

Units in Package 3
Unit Size 4 g packets
Indications For the treatment and control of roundworms (toxocara canis, toxascaris leonina), hookworms (ancylostomia canium, uncinaria stenocephala), whipworms (trichuris vulpis), and tapeworms (taenia pisiformis).
Directions Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. The daily dose is mg/kg (22.7 mg/lb) of body weight. Please refer to the following dosing table for help in finding the right dose for your dog. Dosing Table: 10 pounds: 1 gram, 20 pounds: 2 grams, 30 pounds: 1 gram, 40 pounds: 4 gram, 50 pounds: 1 gram plus 4 gram, 60 pound: 2 gram plus 4 gram, 80 pounds: two 4 gram, over 80 pounds: use combinations to obtain recommended daily dose. Packet size is the daily dose. the dog must be treated wit this dose 3 days in a row. You should weigh your dog to make sure you are using the right size and number of packets. If your dog's weight is in – between the suggested dosing sizes. It is safe to use the next higher size. For example, a 15-pound dog should be treated with the 2-gram packet. Give to your dog by mixing the daily dose with a small amount of the usual food. Make sure your dog eats all of the medicated food. You may need to moisten dry dog food to aid mixing. Repeat the daily dose for three days in row. Deworming schedules may vary depending on the climate where you live and the activity of our dog. The following schedule should be used as general guidance. Newly weaned pups (6 to 8 weeks of age) should be dewormed at 6, 8, 10 and 12 weeks of Age. Treat the dam at the same time as the puppies, dogs over six months of age should be dewormed. at least twice each year. Each deworming requires 3 daily treatments. Storage: Store at controlled room temperature.
Warnings Keep this and all medications out of the reach of children. In US clinical studies 3 of 240 dogs (about 1% of the treated dogs) had vomiting associated with use of this product. When using this product: Safe-Guard Canine is safe for use in puppies 6 weeks or older and adult dogs, including pregnant bitches. Do not deworm a dog or puppy that is sick. Consult your veterinarian for diagnosis of the illness.

Reviews:

15. Safe-Guard Canine Dewormer

Product Details:

Specifications:

Units in Package 3
Unit Size 2 g packets
Indications For the treatment and control of roundworms (toxocara canis, toxascaris leonina), hookworms (ancylostomia canium, uncinaria stenocephala), whipworms (trichuris vulpis), and tapeworms (taenia pisiformis).
Directions Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. The daily dose is 50 mg/kg (22.7 mg/lb) of body weight. Please refer to the following dosing table for help in finding the right dose for your dog. Dosing Table: 10 pounds: 1 gram, 20 pounds: 2 gram, 30 pounds: 1 gram, 40 pounds: 4 gram, 50 pounds: 1 gram plus 4 gram, 60 pounds: 2 gram plus 4 gram, 80 pounds: two 4 gram, over 80 pounds: use combinations to obtain recommended daily dose. Packet size is the daily dose. The dog must be treated with this dose 3 days in a row. You should weigh your dog to make sure you are using the right size and number of packets. If your dog's weight is in-between the suggested dosing sizes. It is safe to use the next higher size. For example, a 15-pound dog should be treated with the 2-gram packet. Give Safe-Guard Canine to your dog by mixing the daily dose with a small amount of the usual food. Make sure your dog eats all of the medicated food. You may need to moisten dry dog food to aid mixing. Repeat the daily dose for three days in row. Deworming schedules may vary depending on the climate where you live and the activity of our dog. The following schedule should be used as general guidance. Newly weaned pups (6 to 8 weeks of age) should be dewormed at 6, 8, 10 and 12 weeks of Age. Treat the dam at the same time as the puppies, dogs over six months of age should be dewormed. at least twice each year. Each deworming requires 3 daily treatments. Storage: Store at controlled room temperature.
Warnings Keep this and all medications out of the reach of children. In US clinical studies 3 of 240 dogs (about 1% of the treated dogs) had vomiting associated with use of this product. When using this product: Safe-Guard Canine is safe for use in puppies 6 weeks or older and adult dogs, including pregnant bitches. Do not deworm a dog or puppy that is sick. Consult your veterinarian for diagnosis of the illness.

Reviews:

16. Intervet Safe-Guard Canine Dewormer – 3 Pack, 1 G Packets

Product Details:

Specifications:

Units in Package 3
Unit Size 1 g packets
Indications For the treatment and control of roundworms (toxocara canis, toxascaris leonina), hookworms (ancylostomia canium, uncinaria stenocephala), whipworms (trichuris vulpis), and tapeworms (taenia pisiformis).
Directions Consult your veterinarian for assistance in the diagnosis, treatment, and control of parastism. The daily dose is mg/kg (22.7 mg/lb) of body weight. Please refer to the following dosing table for help in finding the right dose for your dog. Dosing Table: 10 pounds: 1 gram, 20 pounds: 2 grams, 30 pounds: 1 gram, 40 pounds: 4 gram, 50 pounds: 1 gram plus 4 gram, 60 pound: 2 gram plus 4 grams, 80 pounds: two 4 gram, over 80 pounds: use combinations to obtain recommended daily dose. Packet size is the daily dose. the dog must be treated wit this dose 3 days in a row. You should weigh your dog to make sure you are using the right size and number of packets. If your dog's weight is in – between the suggested dosing sizes. It is safe to use the next higher size. For example, a 15-pound dog should be treated with the 2-gram packet. Give to your dog by mixing the daily dose with a small amount of the usual food. Make sure your dog eats all of the medicated food. You may need to moisten dry dog food to aid mixing. Repeat the daily dose for three days in row. Deworming schedules may vary depending on the climate where you live and the activity of our dog. The following schedule should be used as general guidance. Newly weaned pups (6 to 8 weeks of age). should be dewormed at 6, 8, 10 and 12 weeks of Age. Treat the dam at the same time as the puppies, dogs over six months of age should be dewormed. at least twice each year. Each deworming requires 3 daily treatments. Storage: Store at controlled room temperature.
Warnings Keep this and all medications out of the reach of children. In US clinical studies 3 of 240 dogs (about 1% of the treated dogs) had vomiting associated with use of this product. When using this product: Safe-Guard Canine is safe for use in puppies 6 weeks or older and adult dogs, including pregnant bitches. Do not deworm a dog or puppy that is sick. Consult your veterinarian for diagnosis of the illness.

Reviews:

17. Safe-Guard 4 8-In-1 Canine Dewormer

Product Details:

Specifications:

Assembled Product Weight 0.05 lbs
Animal Type Dog
Assembled Product Dimensions (L x W x H) 0.50 x 3.50 x 5.50 Inches

Reviews:

18. Petarmor 7-Way Deworm Dog Insect Treatment For Dogs, Tablets – 2 Count

Product Details:

Specifications:

Units in Package 2
Directions Directions for Use: For the removal of large roundworms, hookworms and tapeworms in adult dogs or young dogs, weighing more than 25 lbs., administer these tablets according to the weight of the animal. 6.0 lbs to 25.0 lbs: Use the 30 mg size. 25.1 lbs to 50 lbs: Give 1 tablet. 50.1 lbs to 100 lbs: Give 2 tablets. 100.1 lbs to 150 lbs: Give 3 tablets. 150.1 lbs to 200 lbs: Give 4 tablets. Note: For puppies or small dogs weighing less than 25 lbs., use 7 Way De-Wormer Chewable Flavored Dog De-Wormer Tablets for puppies and small dogs. 7 Way De-Wormer Chewables are recommended for dogs 12 weeks of age and older. Offer the proper dosage by hand or in the dog's food container, with our without food. Do not withhold food from your dog prior to or after treatment. Recommended De-Worming Schedule: Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism. De-worming schedules may vary depending on the climate where you live and the activity of your dog.
Ingredients Active Ingredients: Each Flavored Chewable Contains 114 mg Pyrantel Pamoate and 114 mg Praziquantel.
Warnings Keep out of reach of children. For use only as directed on package insert & back panel. Precaution: The safety of 7 Way De-Wormer in breeding dogs and pregnant bitches has not been determined. In case of ingestion by humans, contact a physician immediately. Physicians may contact a Poison Control Center for advice concerning cases of ingestion by humans. Not for human consumption. Store at controlled room temperature 59-86 degrees F (15-30 degrees C). In case of an emergency; call: 1-800-781-4738. Non-emergency; call: 1-800-224-pets (7387).

Reviews:

19. Sergeant's Sentry Worm X Plus 7-Way De-Wormer Large Dog – 6 Count

Product Details:

Specifications:

Assembled Product Weight 0.1000 lb
Animal Type Dog
Assembled Product Dimensions (L x W x H) 9.00 x 5.50 x 1.00 Inches

Reviews:

20. Durvet 2251171 Wormer-Double Strength Liquid Dog

Product Details:

Specifications:

Product Dimensions 2.4 x 2.25 x 5.8 inches; 9.6 Ounces
Item Package Dimensions L x W x H 5.91 x 2.48 x 2.4 inches
Item Dimensions LxWxH 2.4 x 2.25 x 5.8 inches
Target Audience Keyword dogs, rats